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The Structure of p85ni in Class IA Phosphoinositide 3-Kinase Exhibits Interdomain Disorder
Regulation of the Class IA PI 3-kinase involves inhibition and stabilization of the catalytic subunit (p110) by the regulatory subunit (p85). Regulation is achieved by 2 major contacts: a stable interface involving the Adapter-Binding Domain (ABD) of p110 and the inter-SH2 (iSH2) domain of p85, and...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2849757/ https://ncbi.nlm.nih.gov/pubmed/20131869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902171d |
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