Interleukin 18 Coexpression during Respiratory Syncytial Virus Infection Results in Enhanced Disease Mediated by Natural Killer Cells

Respiratory syncytial virus (RSV) causes bronchiolitis, the main cause of infantile hospitalization. Immunity against reinfection is poor, and there is great interest in boosting vaccine responses using live vectors expressing host cytokines. We therefore constructed a recombinant RSV expressing mur...

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Détails bibliographiques
Auteurs principaux: Harker, James A., Godlee, Alexandra, Wahlsten, Jennifer L., Lee, Debbie C. P., Thorne, Lucy G., Sawant, Devika, Tregoning, John S., Caspi, Rachel R., Bukreyev, Alexander, Collins, Peter L., Openshaw, Peter J. M.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2010
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849516/
https://ncbi.nlm.nih.gov/pubmed/20130064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02014-09
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