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Proliferation Capacity and Cytotoxic Activity Are Mediated by Functionally and Phenotypically Distinct Virus-Specific CD8 T Cells Defined by Interleukin-7Rα (CD127) and Perforin Expression

Cytotoxicity and proliferation capacity are key functions of antiviral CD8 T cells. In the present study, we investigated a series of markers to define these functions in virus-specific CD8 T cells. We provide evidence that there is a lack of coexpression of perforin and CD127 in human CD8 T cells....

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Autori principali: Cellerai, Cristina, Perreau, Matthieu, Rozot, Virginie, Enders, Felicitas Bellutti, Pantaleo, Giuseppe, Harari, Alexandre
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849500/
https://ncbi.nlm.nih.gov/pubmed/20130059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02565-09
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