Dominant TNF-α(+) Mycobacterium tuberculosis–specific CD4(+) T cell responses discriminate between latent infection and active disease

Rapid diagnosis of active Mycobacterium tuberculosis (Mtb) infection remains a clinical and laboratory challenge. We have analyzed the cytokine profile (interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2)) of Mtb-specific T cells by polychromatic flow cytometry. We studied...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Harari, Alexandre, Rozot, Virginie, Enders, Felicitas Bellutti, Perreau, Matthieu, Stalder, Jesica Mazza, Nicod, Laurent P, Cavassini, Matthias, Calandra, Thierry, Blanchet, Catherine Lazor, Jaton, Katia, Faouzi, Mohamed, Day, Cheryl L, Hanekom, Willem A, Bart, Pierre-Alexandre, Pantaleo, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570988/
https://ncbi.nlm.nih.gov/pubmed/21336285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2299
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