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Uncoupling of Expression of an Intronic MicroRNA and Its Myosin Host Gene by Exon Skipping
The ancient MYH7b gene, expressed in striated muscle and brain, encodes a sarcomeric myosin and the intronic microRNA miR-499. We find that skipping of an exon introduces a premature termination codon in the transcript that downregulates MYH7b protein production without affecting microRNA expression...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2849460/ https://ncbi.nlm.nih.gov/pubmed/20154144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01370-09 |
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