Pradimicin S, a Highly Soluble Nonpeptidic Small-Size Carbohydrate-Binding Antibiotic, Is an Anti-HIV Drug Lead for both Microbicidal and Systemic Use

Pradimicin S (PRM-S) is a highly water-soluble, negatively charged derivative of the antibiotic pradimicin A (PRM-A) in which the terminal xylose moiety has been replaced by 3-sulfated glucose. PRM-S does not prevent human immunodeficiency virus (HIV) adsorption on CD4(+) T cells, but it blocks viru...

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Detalhes bibliográficos
Main Authors: Balzarini, Jan, François, Katrien O., Van Laethem, Kristel, Hoorelbeke, Bart, Renders, Marleen, Auwerx, Joeri, Liekens, Sandra, Oki, Toshikazu, Igarashi, Yasuhiro, Schols, Dominique
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849379/
https://ncbi.nlm.nih.gov/pubmed/20047920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01347-09
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