Actinohivin, a Broadly Neutralizing Prokaryotic Lectin, Inhibits HIV-1 Infection by Specifically Targeting High-Mannose-Type Glycans on the gp120 Envelope

The lectin actinohivin (AH) is a monomeric carbohydrate-binding agent (CBA) with three carbohydrate-binding sites. AH strongly interacts with gp120 derived from different X4 and R5 human immunodeficiency virus (HIV) strains, simian immunodeficiency virus (SIV) gp130, and HIV type 1 (HIV-1) gp41 with...

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Detalhes bibliográficos
Main Authors: Hoorelbeke, Bart, Huskens, Dana, Férir, Geoffrey, François, Katrien O., Takahashi, Atsushi, Van Laethem, Kristel, Schols, Dominique, Tanaka, Haruo, Balzarini, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916299/
https://ncbi.nlm.nih.gov/pubmed/20498311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00254-10
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