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From Induced Fit to Conformational Selection: A Continuum of Binding Mechanism Controlled by the Timescale of Conformational Transitions
In receptor-ligand binding, a question that generated considerable interest is whether the mechanism is induced fit or conformational selection. This question is addressed here by a solvable model, in which a receptor undergoes transitions between active and inactive forms. The inactive form is favo...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2849054/ https://ncbi.nlm.nih.gov/pubmed/20303846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.11.029 |
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