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Both protein dynamics and ligand concentration can shift the binding mechanism between conformational selection and induced fit
This study aimed to shed light on the long debate over whether conformational selection (CS) or induced fit (IF) is the governing mechanism for protein–ligand binding. The main difference between the two scenarios is whether the conformational transition of the protein from the unbound form to the b...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4104862/ https://ncbi.nlm.nih.gov/pubmed/24982141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407545111 |
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