Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination

The androgen receptor (AR) plays a critical role in prostate cancer. We have identified an ubiquitin E3 ligase RNF6 as one of AR-associated proteins in a proteomic screen. RNF6 induces AR ubiquitination and promotes AR transcriptional activity. Specific knockdown of RNF6 or mutation of RNF6-induced...

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Bibliografiske detaljer
Main Authors: Xu, Kexin, Shimelis, Hermela, Linn, Douglas E., Jiang, Richeng, Yang, Xi, Sun, Feng, Guo, Zhiyong, Chen, Hege, Li, Wei, Chen, Hegang, Kong, Xiangtian, Melamed, Jonathan, Fang, Shengyun, Xiao, Zhen, Veenstra, Timothy D., Qiu, Yun
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848969/
https://ncbi.nlm.nih.gov/pubmed/19345326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.02.021
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