Differential Regulation of Androgen Receptor by PIM-1 Kinases via Phosphorylation-dependent Recruitment of Distinct Ubiquitin E3 Ligases

Androgen receptor (AR) plays a pivotal role in prostate cancer. Regulation of AR transcriptional activity by post-translational modifications, such as phosphorylation by multiple kinases, is well documented. Here, we report that two PIM-1 kinase isoforms which are up-regulated during prostate cancer...

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Detalhes bibliográficos
Main Authors: Linn, Douglas E., Yang, Xi, Xie, Yingqiu, Alfano, Alan, Deshmukh, Dhanraj, Wang, Xin, Shimelis, Hermela, Chen, Hegang, Li, Wei, Xu, Kexin, Chen, Mingyuan, Qiu, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391098/
https://ncbi.nlm.nih.gov/pubmed/22584579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.338350
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