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Inhibition of Pyk2 Blocks Airway Inflammation and Hyperresponsiveness in a Mouse Model of Asthma

The objective of this investigation was to determine the role of Pyk2, an intracellular nonreceptor protein tyrosine kinase for postadhesive inflammatory cell migration, on airway inflammation and hyperresponsiveness in immune-sensitized mice. Blockade of Pyk2 was effected by intraperitoneal adminis...

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Библиографические подробности
Главные авторы: Duan, Yingli, Learoyd, Jonathan, Meliton, Angelo Y., Clay, Bryan S., Leff, Alan R., Zhu, Xiangdong
Формат: Artigo
Язык:Inglês
Опубликовано: American Thoracic Society 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848740/
https://ncbi.nlm.nih.gov/pubmed/19520918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0469OC
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