No cardiac effects of therapeutic and supratherapeutic doses of rupatadine: results from a ‘thorough QT/QTc study’ performed according to ICH guidelines

AIMS: To evaluate the effects of therapeutic and supratherapeutic doses of rupatadine on cardiac repolarization in line with a ‘thorough QT/QTc study’ protocol performed according to International Conference on Harmonization guidelines. METHODS: This was a randomized (gender-balanced), parallel-grou...

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Detalhes bibliográficos
Main Authors: Donado, Ester, Izquierdo, Iñaki, Pérez, Iñaki, García, Olga, Antonijoan, Rosa Ma, Gich, Ignaci, Solans, Anna, Peña, Juana, Morganroth, Joel, Barbanoj, Manuel J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Methods in Clinical Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848413/
https://ncbi.nlm.nih.gov/pubmed/20406224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03599.x
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