An Accessory to the ‘Trinity’: SR-As Are Essential Pathogen Sensors of Extracellular dsRNA, Mediating Entry and Leading to Subsequent Type I IFN Responses

Extracellular RNA is becoming increasingly recognized as a signaling molecule. Virally derived double stranded (ds)RNA released into the extracellular space during virus induced cell lysis acts as a powerful inducer of classical type I interferon (IFN) responses; however, the receptor that mediates...

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Hauptverfasser: DeWitte-Orr, Stephanie J., Collins, Susan E., Bauer, Carla M. T., Bowdish, Dawn M., Mossman, Karen L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847946/
https://ncbi.nlm.nih.gov/pubmed/20360967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000829
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