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Ligand-modified gene carriers increased uptake in target cells but reduced DNA release and transfection efficiency

DNA delivery to cells can be improved by using particle carriers made from biodegradable polymers such as PLGA. It is speculated that addition of targeting moieties to the particle surface to facilitate uptake can further enhance gene expression in specific cells or tissues. Taking advantage of well...

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Bibliografski detalji
Glavni autori: Cu, Yen, LeMoëllic, Cathy, Caplan, Michael J., Saltzman, W. Mark
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847641/
https://ncbi.nlm.nih.gov/pubmed/19800989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2009.09.001
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