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Effect of channel mutations on the uptake and release of the retinal ligand in opsin
In the retinal binding pocket of rhodopsin, a Schiff base links the retinal ligand covalently to the Lys296 side chain. Light transforms the inverse agonist 11-cis-retinal into the agonist all-trans-retinal, leading to the active Meta II state. Crystal structures of Meta II and the active conformati...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3325672/ https://ncbi.nlm.nih.gov/pubmed/22431612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117268109 |
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