A Ligand Channel through the G Protein Coupled Receptor Opsin

The G protein coupled receptor rhodopsin contains a pocket within its seven-transmembrane helix (TM) structure, which bears the inactivating 11-cis-retinal bound by a protonated Schiff-base to Lys296 in TM7. Light-induced 11-cis-/all-trans-isomerization leads to the Schiff-base deprotonated active M...

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Detalhes bibliográficos
Main Authors: Hildebrand, Peter W., Scheerer, Patrick, Park, Jung Hee, Choe, Hui-Woog, Piechnick, Ronny, Ernst, Oliver P., Hofmann, Klaus Peter, Heck, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632885/
https://ncbi.nlm.nih.gov/pubmed/19194506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004382
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