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Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface
Extracellular signals prompt G protein-coupled receptors (GPCRs) to adopt an active conformation (R*) and catalyze GDP/GTP exchange in the α-subunit of intracellular G proteins (Gαβγ). Kinetic analysis of transducin (G(t)αβγ) activation shows that an intermediary R*·G(t)αβγ·GDP complex is formed tha...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2705592/ https://ncbi.nlm.nih.gov/pubmed/19541654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900072106 |
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