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Ligand-modified gene carriers increased uptake in target cells but reduced DNA release and transfection efficiency
DNA delivery to cells can be improved by using particle carriers made from biodegradable polymers such as PLGA. It is speculated that addition of targeting moieties to the particle surface to facilitate uptake can further enhance gene expression in specific cells or tissues. Taking advantage of well...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2847641/ https://ncbi.nlm.nih.gov/pubmed/19800989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2009.09.001 |
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