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Structural Comparisons of Class I Phosphoinositide 3-kinases
Class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate cell growth. One of these kinases, PI3Kα, is frequently mutated in diverse tumor types. The recently determined structure of PI3Kα reveals features that distinguish this enzyme from related lipid kinases. In addition, wild-ty...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2847604/ https://ncbi.nlm.nih.gov/pubmed/18633356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2443 |
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