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FUNCTIONAL DISSECTION OF SIRT6: IDENTIFICATION OF DOMAINS THAT REGULATE HISTONE DEACETYLASE ACTIVITY AND CHROMATIN LOCALIZATION

The mammalian sirtuin SIRT6 is a site-specific histone deacetylase that regulates chromatin structure. SIRT6 is implicated in fundamental biological processes in aging, including maintaining telomere integrity, fine-tuning aging-associated gene expression programs, preventing genomic instability, an...

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Detalhes bibliográficos
Main Authors: Tennen, Ruth I., Berber, Elisabeth, Chua, Katrin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846990/
https://ncbi.nlm.nih.gov/pubmed/20117128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2010.01.006
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