Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common known cause of Parkinson's disease (PD). Whether loss of LRRK2 function accounts for neurodegeneration of dopamine neurons in PD is not known, nor is it known whether LRRK2 kinase activity modulates the susceptibilit...

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Main Authors: Andres-Mateos, Eva, Mejias, Rebeca, Sasaki, Masayuki, Li, Xiaojie, Lin, Brian M., Biskup, Saskia, Zhang, Li, Banerjee, Rebecca, Thomas, Bobby, Yang, Lichuan, Liu, Guosheng, Beal, M. Flint, Huso, David L., Dawson, Ted M., Dawson, Valina L.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846613/
https://ncbi.nlm.nih.gov/pubmed/20016100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4357-09.2009
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