The unfolded protein response signals through high-order assembly of Ire1

Aberrant folding of proteins in the endoplasmic reticulum activates the bifunctional transmembrane kinase/endoribonuclease Ire1. Ire1 excises an intron from HAC1 messenger RNA in yeasts and Xbp1 messenger RNA in metozoans encoding homologous transcription factors. This non-conventional mRNA splicing...

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Hlavní autoři: Korennykh, Alexei V., Egea, Pascal F., Korostelev, Andrei A., Finer-Moore, Janet, Zhang, Chao, Shokat, Kevan M., Stroud, Robert M., Walter, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846394/
https://ncbi.nlm.nih.gov/pubmed/19079236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07661
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