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DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human α-syn toxicity
Parkinson's disease (PD) is the most common neurodegenerative movement disorder. A pathological hallmark of PD is the presence of intraneuronal inclusions composed of fibrillized α-synuclein (α-syn) in affected brain regions. Mutations in the gene, PARK7, which encodes DJ-1, can cause autosomal...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2846158/ https://ncbi.nlm.nih.gov/pubmed/20089532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq017 |
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