A New Steroidal 5,7-Diene Derivative, 3β-Hydroxyandrosta-5, 7-Diene-17β-Carboxylic Acid, Shows Potent Anti-proliferative Activity

The new steroidal 5,7-diene, 3β-hydroxyandrosta-5,7-diene-17β-carboxylic acid (17-COOH-7DA), was synthesized from 21-acetoxypregnenolone, with the oxidative cleavage of the side chain being dependent on the presence of oxygen. In human epidermal (HaCaT) keratinocytes, 17-COOH-7DA inhibited prolifera...

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Detalhes bibliográficos
Main Authors: Kim, Tae-Kang, Chen, Jianjun, Li, Wei, Zjawiony, Jordan, Miller, Duane, Janjetovic, Zorica, Tuckey, Robert C, Slominski, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846116/
https://ncbi.nlm.nih.gov/pubmed/20025893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2009.12.004
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