Photo-conversion of two epimers (20R and 20S) of pregna-5,7-diene-3β,17α,20-triol and their bioactivity in melanoma cells

Pregna-5,7-dienes and their hydroxylated derivatives can be formed in vivo when there is a deficiency in 7-dehydrocholesterol (7-DHC) Δ-reductase function, e.g., Smith-Lemli-Opitz syndrome (SLOS). Ultraviolet B (UVB) radiation induces photoconversion of 7-DHC to vitamin D(3), lumisterol(3) and tachy...

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Detalhes bibliográficos
Main Authors: Zmijewski, Michal A., Li, Wei, Zjawiony, Jordan K., Sweatman, Trevor W., Chen, Jianjun, Miller, Duane D., Slominski, Andrzej T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631623/
https://ncbi.nlm.nih.gov/pubmed/19028513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2008.10.017
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