Synthesis and photochemical transformation of 3β,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity

We have synthesized 3β,21-dihydroxypregna-5,7-dien-20-one (21(OH) 7DHP) and used UVB radiation to induce its photoconversion to analogues of vitamin D (pD), lumisterol (pL) and tachysterol (pT). The number and character of the products and the dynamics of the process were dependent on the UVB dose....

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Main Authors: Zmijewski, Michal A., Li, Wei, Chen, Jianjun, Kim, Tae-Kang, Zjawiony, Jordan K., Sweatman, Trevor W., Miller, Duane D., Slominski, Andrzej T.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005096/
https://ncbi.nlm.nih.gov/pubmed/21070794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2010.10.009
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