Loss of the Acinar-Restricted Transcription Factor Mist1 Accelerates Kras-Induced Pancreatic Intraepithelial Neoplasia

BACKGROUND & AIMS: Invasive pancreatic ductal adenocarcinoma is thought to originate from duct-like lesions called pancreatic intraepithelial neoplasia (PanIN). PanINs progress from low grade (PanIN-1) to high grade (PanIN-3) as the cells attain molecular alterations to key regulatory genes, inc...

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Autori principali: Shi, Guanglu, Zhu, Liqin, Sun, Yan, Bettencourt, Ryan, Damsz, Barbara, Hruban, Ralph H., Konieczny, Stephen F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845927/
https://ncbi.nlm.nih.gov/pubmed/19249398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.12.066
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