Physical Association of PDK1 with AKT1 Is Sufficient for Pathway Activation Independent of Membrane Localization and Phosphatidylinositol 3 Kinase

Frequent activation of the AKT serine-threonine kinase in cancer confers resistance to therapy. AKT is activated by a multi-step process involving phosphatidylinositide (PtdIns) phosphate-mediated recruitment of AKT and its upstream kinases, including 3-Phosphoinositide-dependent kinase 1 (PDK1), to...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Ding, Zhiyong, Liang, Jiyong, Li, Jin, Lu, Yiling, Ariyaratna, Vathsala, Lu, Zhimin, Davies, Michael A., Westwick, John K., Mills, Gordon B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845649/
https://ncbi.nlm.nih.gov/pubmed/20361045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009910
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars