Products of Vitamin D3 or 7-Dehydrocholesterol Metabolism by Cytochrome P450scc Show Anti-Leukemia Effects, Having Low or Absent Calcemic Activity

BACKGROUND: Cytochrome P450scc metabolizes vitamin D3 to 20-hydroxyvitamin D3 (20(OH)D3) and 20,23(OH)(2)D3, as well as 1-hydroxyvitamin D3 to 1α,20-dihydroxyvitamin D3 (1,20(OH)(2)D3). It also cleaves the side chain of 7-dehydrocholesterol producing 7-dehydropregnenolone (7DHP), which can be transf...

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Detalhes bibliográficos
Main Authors: Slominski, Andrzej T., Janjetovic, Zorica, Fuller, Brian E., Zmijewski, Michal A., Tuckey, Robert C., Nguyen, Minh N., Sweatman, Trevor, Li, Wei, Zjawiony, Jordan, Miller, Duane, Chen, Tai C., Lozanski, Gerard, Holick, Michael F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845617/
https://ncbi.nlm.nih.gov/pubmed/20360850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009907
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