Ssz1 Restores Endoplasmic Reticulum-Associated Protein Degradation in Cells Expressing Defective Cdc48–Ufd1–Npl4 Complex by Upregulating Cdc48

The endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway eliminates aberrant proteins from the ER. The key role of Cdc48p–Ufd1p–Npl4p is indicated by impaired ERAD in Saccharomyces cerevisiae with mutations in any of this complex's genes. We identified SSZ1 in genetic screen...

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Hlavní autoři: Bosis, Eran, Salomon, Dor, Ohayon, Orit, Sivan, Gilad, Bar-Nun, Shoshana, Rabinovich, Efrat
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2010
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Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845338/
https://ncbi.nlm.nih.gov/pubmed/20038635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.109.111419
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