Peruvian and globally reported amino acid substitutions on the Mycobacterium tuberculosis pyrazinamidase suggest a conserved pattern of mutations associated to pyrazinamide resistance

Resistance to pyrazinamide in Mycobacterium tuberculosis is usually associated with a reduction of pyrazinamidase activity caused by mutations in pncA, the pyrazinamidase coding gene. Pyrazinamidase is a hydrolase that converts pyrazinamide, the antituberculous drug against the latent stage, to the...

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Bibliographic Details
Main Authors: Zimic, Mirko, Sheen, Patricia, Quiliano, Miguel, Gutierrez, Andrés, Gilman, Robert H.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845309/
https://ncbi.nlm.nih.gov/pubmed/19963078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.meegid.2009.11.016
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