Endogenous Bak inhibitors Mcl-1 and Bcl-x(L): differential impact on TRAIL resistance in Bax-deficient carcinoma

Tumor necrosis factor (α)–related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent that preferentially kills tumor cells with limited cytotoxicity to nonmalignant cells. However, signaling from death receptors requires amplification via the mitochondrial apoptosis pathway (type II)...

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Detalhes bibliográficos
Main Authors: Gillissen, Bernhard, Wendt, Jana, Richter, Antje, Richter, Anja, Müer, Annika, Overkamp, Tim, Gebhardt, Nina, Preissner, Robert, Belka, Claus, Dörken, Bernd, Daniel, Peter T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845080/
https://ncbi.nlm.nih.gov/pubmed/20308427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200912070
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