Targeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent ‘type I' mode

TRAIL is a promising anticancer agent, capable of inducing apoptosis in a wide range of treatment-resistant tumor cells. In ‘type II' cells, the death signal triggered by TRAIL requires amplification via the mitochondrial apoptosis pathway. Consequently, deregulation of the intrinsic apoptosis-...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Gillissen, B, Richter, A, Overkamp, T, Essmann, F, Hemmati, P G, Preissner, R, Belka, C, Daniel, P T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674381/
https://ncbi.nlm.nih.gov/pubmed/23703388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.67
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados