Tetherin inhibits HIV-1 release by directly tethering virions to cells

Tetherin is an interferon-induced protein whose expression blocks the release of HIV-1 and other enveloped viral particles. The underlying mechanism by which tetherin functions, and whether it directly or indirectly causes virion retention are unknown. Here, we elucidate the mechanism by which tethe...

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Main Authors: Perez-Caballero, David, Zang, Trinity, Ebrahimi, Alaleh, McNatt, Matthew W., Gregory, Devon A., Johnson, Marc C., Bieniasz, Paul D.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844890/
https://ncbi.nlm.nih.gov/pubmed/19879838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.08.039
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