Structural insight into the mechanisms of enveloped virus tethering by tetherin

Tetherin/BST2 is a type-II membrane protein that inhibits the release of a range of enveloped viruses, including HIV-1. Here we report three crystal structures of human tetherin, including the full-length ectodomain, a triple cysteine mutant and an ectodomain truncation. These structures show that t...

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Detalhes bibliográficos
Main Authors: Yang, Haitao, Wang, Jimin, Jia, Xiaofei, McNatt, Matthew W., Zang, Trinity, Pan, Baocheng, Meng, Wuyi, Wang, Hong-Wei, Bieniasz, Paul D., Xiong, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972963/
https://ncbi.nlm.nih.gov/pubmed/20940320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011485107
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