Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain Variants

Tetherin/BST-2/CD317 is a recently identified antiviral protein that blocks the release of nascent retrovirus, and other virus, particles from infected cells. An HIV-1 accessory protein, Vpu, acts as an antagonist of tetherin. Here, we show that positive selection is evident in primate tetherin sequ...

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Detalhes bibliográficos
Main Authors: McNatt, Matthew W., Zang, Trinity, Hatziioannou, Theodora, Bartlett, Mackenzie, Fofana, Ismael Ben, Johnson, Welkin E., Neil, Stuart J. D., Bieniasz, Paul D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633611/
https://ncbi.nlm.nih.gov/pubmed/19214216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000300
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