Compensatory Increases in Nuclear PGC1α Protein Are Primarily Associated With Subsarcolemmal Mitochondrial Adaptations in ZDF Rats

OBJECTIVE: We examined in insulin-resistant muscle if, in contrast to long-standing dogma, mitochondrial fatty acid oxidation is increased and whether this is attributed to an increased nuclear content of peroxisome proliferator–activated receptor (PPAR) γ coactivator (PGC) 1α and the adaptations of...

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Autores principales: Holloway, Graham P., Gurd, Brendon J., Snook, Laelie A., Lally, Jamie, Bonen, Arend
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844829/
https://ncbi.nlm.nih.gov/pubmed/20103701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1519
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