The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis

Deacetylation of PGC-1α by SIRT1 is thought to be an important step in increasing PGC-1α transcriptional activity, since in muscle cell lines SIRT1 induces PGC-1α protein expression and mitochondrial biogenesis. We examined the relationship between SIRT1 protein and activity, PGC-1α and markers of m...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Gurd, Brendon J, Yoshida, Yuko, Lally, James, Holloway, Graham P, Bonen, Arend
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2009
Témata:
Integrative
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683967/
https://ncbi.nlm.nih.gov/pubmed/19237425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.168096
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky