The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis

Deacetylation of PGC-1α by SIRT1 is thought to be an important step in increasing PGC-1α transcriptional activity, since in muscle cell lines SIRT1 induces PGC-1α protein expression and mitochondrial biogenesis. We examined the relationship between SIRT1 protein and activity, PGC-1α and markers of m...

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Bibliographische Detailangaben
Hauptverfasser: Gurd, Brendon J, Yoshida, Yuko, Lally, James, Holloway, Graham P, Bonen, Arend
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2009
Schlagworte:
Integrative
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683967/
https://ncbi.nlm.nih.gov/pubmed/19237425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.168096
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