Activity of the Kinesin Spindle Protein Inhibitor Ispinesib (SB-715992) in Models of Breast Cancer

PURPOSE: Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis. Clinical studies of ispinesib have shown a 9% response rate in patients with locally advanced...

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Main Authors: Purcell, James W., Davis, Jefferson, Reddy, Mamatha, Martin, Shamra, Samayoa, Kimberly, Vo, Hung, Thomsen, Karen, Bean, Peter, Kuo, Wen Lin, Ziyad, Safiyyah, Billig, Jessica, Feiler, Heidi S., Gray, Joe W., Wood, Kenneth W., Cases, Sylvaine
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844774/
https://ncbi.nlm.nih.gov/pubmed/20068098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1498
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