Activity of the Kinesin Spindle Protein Inhibitor Ispinesib (SB-715992) in Models of Breast Cancer

PURPOSE: Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis. Clinical studies of ispinesib have shown a 9% response rate in patients with locally advanced...

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Detaylı Bibliyografya
Asıl Yazarlar: Purcell, James W., Davis, Jefferson, Reddy, Mamatha, Martin, Shamra, Samayoa, Kimberly, Vo, Hung, Thomsen, Karen, Bean, Peter, Kuo, Wen Lin, Ziyad, Safiyyah, Billig, Jessica, Feiler, Heidi S., Gray, Joe W., Wood, Kenneth W., Cases, Sylvaine
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844774/
https://ncbi.nlm.nih.gov/pubmed/20068098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1498
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