Metal-Dependent Cytotoxic and Kinesin Spindle Protein Inhibitory Activity of Ru, Os, Rh, and Ir Half-Sandwich Complexes of Ispinesib-Derived Ligands

[Image: see text] Ispinesib is a potent inhibitor of kinesin spindle protein (KSP), which has been identified as a promising target for antimitotic anticancer drugs. Herein, we report the synthesis of half-sandwich complexes of Ru, Os, Rh, and Ir bearing the ispinesib-derived N,N-bidentate ligands (...

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Publicado no:Inorg Chem
Main Authors: Łomzik, Michał, Hanif, Muhammad, Budniok, Aleksandra, Błauż, Andrzej, Makal, Anna, Tchoń, Daniel M., Leśniewska, Barbara, Tong, Kelvin K. H., Movassaghi, Sanam, Söhnel, Tilo, Jamieson, Stephen M. F., Zafar, Ayesha, Reynisson, Jóhannes, Rychlik, Błażej, Hartinger, Christian G., Plażuk, Damian
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584371/
https://ncbi.nlm.nih.gov/pubmed/33003697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.inorgchem.0c00957
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