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Studies Towards Paraherquamides E & F and Related (13)C-labeled Putative Biosynthetic Intermediates: Stereocontrolled Synthesis of the α-Alkyl-β-Methylproline Ring System

A substituted 2R-allyl-3S-methylproline ethyl ester suitable for elaboration to paraherquamides E, F and related (13)C-labelled putative biosynthesis intermediates have been prepared efficiently in six steps and 24% overall yield. The key steps are a 5-exo-trig cyclization of a zinc enolate on an un...

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Detalhes bibliográficos
Main Authors: Sommer, Konrad, Williams, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844772/
https://ncbi.nlm.nih.gov/pubmed/20336192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2008.05.068
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