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Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway

The paraherquamides are potent anthelmintic natural products with complex heptacyclic scaffolds. One key feature of these molecules is the spiro-oxindole moiety that lends a strained three-dimensional architecture to these structures. The flavin monooxygenase PhqK was found to catalyze spirocycle fo...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Fraley, Amy E., Haatveit, Kersti Caddell, Ye, Ying, Kelly, Samantha P., Newmister, Sean A., Yu, Fengan, Williams, Robert M., Smith, Janet L., Houk, K. N., Sherman, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065246/
https://ncbi.nlm.nih.gov/pubmed/31904957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b09070
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