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Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway
The paraherquamides are potent anthelmintic natural products with complex heptacyclic scaffolds. One key feature of these molecules is the spiro-oxindole moiety that lends a strained three-dimensional architecture to these structures. The flavin monooxygenase PhqK was found to catalyze spirocycle fo...
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| Udgivet i: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7065246/ https://ncbi.nlm.nih.gov/pubmed/31904957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b09070 |
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