The H-loop in the Second Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator is Required for Efficient Chloride Channel Closing

The cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-binding cassette (ABC) transporter that functions as a cAMP-activated chloride channel. The recent model of CFTR gating predicts that the ATP binding to both nucleotide-binding domains (NBD1 and NBD2) of CFTR is required for th...

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Hauptverfasser: Kloch, Monika, Milewski, Michał, Nurowska, Ewa, Dworakowska, Beata, Cutting, Garry R., Dołowy, Krzysztof
Format: Artigo
Sprache:Inglês
Veröffentlicht: S. Karger AG 2010
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844707/
https://ncbi.nlm.nih.gov/pubmed/20110677
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