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The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex
Sonic hedgehog (Shh) and its main receptor Patched (Ptc) are implicated in both neural development and tumorigenesis1, 2. Beside the classic morphogen activity of Shh, Shh is also a survival factor3, 4. Along this line, Ptc has been shown to function as a dependence receptor, inducing apoptosis in t...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Macmillan Magazines Ltd.
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844407/ https://ncbi.nlm.nih.gov/pubmed/19465923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1880 |
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