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Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9
Patched (Ptc), the main receptor for Sonic Hedghog, is a tumor suppressor. Ptc has been shown to be a dependence receptor, and as such triggers apoptosis in the absence of its ligand. This apoptosis induction occurs through the recruitment by the Ptc intracellular domain of a caspase-activating comp...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3387056/ https://ncbi.nlm.nih.gov/pubmed/22679284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200094109 |
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