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Blocking SHH/Patched interaction triggers tumor growth inhibition through Patched-induced apoptosis
The Hedgehog (HH) pathway plays a key role in cancer. Alterations of HH canonical signaling pathway, causally linked to tumor progression, have become rational targets for cancer therapy. However, Smo inhibitors have failed to show clinical benefit in patients with cancers displaying SHH autocrine/p...
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| Gepubliceerd in: | Cancer Res |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7231656/ https://ncbi.nlm.nih.gov/pubmed/32060146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1340 |
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