Ciz1 cooperates with cyclin-A–CDK2 to activate mammalian DNA replication in vitro

Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs). Under these conditions, cyclin E supports pre-replication complex assembly, whereas cyclin-A-associated kinase acts later to termin...

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Main Authors: Copeland, Nikki A., Sercombe, Heather E., Ainscough, Justin F. X., Coverley, Dawn
Formato: Artigo
Idioma:Inglês
Publicado: Company of Biologists 2010
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844319/
https://ncbi.nlm.nih.gov/pubmed/20215406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.059345
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